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 This volume provides a detailed summary of knowledge regarding the development of the trophoblast during the First Trimester of Pregnancy, the process of placenta apoptosis and the factors causing aging of the placenta. The pathology of trophoblast can manifest itself in several clinical conditions during pregnancy such as intrauterine foetal growth restriction (IUGR), gestational trophoblastic disease and pre-eclampsia. The analysis of the pathogenetic mechanisms involved in these critical conditions are discussed in this book. These aspects are analysed with scientific methodology on the basis of updated studies. "Development of Human Trophoblast" can be considered a reference book for every pathologist, obstetrician and resident.